PGT-A / PGT-M (Genetic Screening) in Delhi
Embryos are biopsied and screened for chromosomal abnormality or a specific inherited disease.
What PGT-A / PGT-M involves
Preimplantation genetic testing takes a few cells from the outer layer of a day-five blastocyst and analyses them. PGT-A screens for the wrong number of chromosomes, the commonest cause of implantation failure and early miscarriage. PGT-M tests for one specific inherited condition that the couple is known to carry.
Biopsy samples are processed through an accredited reproductive-genetics laboratory with a defined turnaround, and the result is explained in a dedicated counselling session rather than handed over as a printout. We recommend testing where there is a documented indication, not as a routine upsell.
Who this is for
- Maternal age above 37, where aneuploidy rates rise sharply
- Two or more miscarriages, or repeated implantation failure
- A known single-gene disorder such as thalassaemia or cystic fibrosis
- A balanced translocation in either partner
Not everything on this list means you need this treatment. The workup comes first, and the recommendation follows from what it shows — not from what was booked before you arrived.
Step by step
Genetic counselling
A formal session establishing whether testing will actually change your outcome.
Blastocyst biopsy
A few trophectoderm cells are removed on day five without touching the cells that form the baby.
Freeze and analyse
Embryos are vitrified while the laboratory analyses the samples.
Transfer of a tested embryo
A euploid or unaffected embryo is transferred in a later prepared cycle.
Your results, in writing
Whatever the outcome of PGT-A / PGT-M, you leave each stage with the findings written down — what was done, what was found, what it means, and what the options are from here. Reports are issued the same day wherever the laboratory allows it.
Case study: Three miscarriages and a balanced translocation
35, Nehru Place · three first-trimester losses · conceives easily
What she came in with
She conceived within two months each time and miscarried at eight, nine and seven weeks. Conception was clearly not the problem. Two centres had investigated her for clotting disorders and found nothing.
What the workup showed
Parental karyotyping — which had not been done — showed a balanced reciprocal translocation in her husband between chromosomes 11 and 22. He is entirely healthy; his sperm carry a high proportion of unbalanced chromosome arrangements, which is what was causing the losses.
What we did
Genetic counselling, then an IVF cycle with PGT-SR on blastocyst biopsies. Of nine blastocysts tested, three were balanced or normal and six were unbalanced.
Outcome
A single tested embryo transfer produced an ongoing pregnancy that went to term. Two tested embryos remain frozen.
The point of this case
Three pregnancy losses had been attributed to her. A blood test on her husband, costing very little, found the actual cause after the second loss would have been the right time to do it.
Illustrative case. This is a composite of presentations commonly seen in this practice, written for explanation — it is not the record of an identifiable patient, and no individual's details are used. Outcomes vary, and nothing here is a prediction of what will happen in your case.
What is different about having this done here
In-house reproductive genetics laboratory
Genetic counselling before testing, not after
Clear reporting, including inconclusive and mosaic results
Honest advice when testing would not improve your odds
Treated by the consultant, not by a rotating team
Dr. Tiwari performs the scans, the procedure and the follow-up herself, and looks after any pregnancy that results. Over a long treatment course that continuity is the difference between being known and being processed.
- MBBS, MS (Obstetrics & Gynaecology), FNB (Reproductive Medicine)
- Over ten years in reproductive medicine and gynaecological surgery
- Consultations and scans at Mother's Hope, Katwaria Sarai; theatre work at SHE Delhi Hospital, Greater Kailash II
- Itemised costs given in writing before anything begins
Areas we see patients from
Both locations are in South Delhi. Patients travelling from further out have appointments grouped to cut down the number of trips.
Questions about PGT-A / PGT-M
Does PGT-A improve my chances?
It improves the chance per transfer and reduces miscarriage, particularly over 37. It does not increase the chance of a live birth per egg collection in younger women, and we say so.
Is embryo biopsy safe?
Performed on a blastocyst by an experienced embryologist, it does not measurably reduce implantation. The cells taken are from the layer that becomes placenta.
What is a mosaic embryo?
One showing a mix of normal and abnormal cells. Some mosaic embryos produce healthy babies. These results need proper counselling, which is included.
Talk it through before you commit
Consultations run for a full hour. Bring any previous reports — they are reviewed properly, not repeated.