IMSI & PICSI in Delhi
Advanced sperm selection at very high magnification, or by binding affinity, before injection.
What IMSI & PICSI involves
IMSI examines sperm at magnifications above 6,000x to detect vacuoles and structural defects invisible at routine magnification. PICSI selects sperm by their ability to bind hyaluronan, mimicking what happens naturally at the egg's outer layer.
Both are refinements of ICSI, used selectively rather than routinely. We recommend them where sperm morphology is severely abnormal, where DNA fragmentation is high, or after repeated poor embryo quality with no other explanation.
Who this is for
- Severe teratozoospermia with very low normal forms
- High sperm DNA fragmentation index
- Repeated poor embryo development in previous cycles
- Recurrent miscarriage with a suspected sperm contribution
Not everything on this list means you need this treatment. The workup comes first, and the recommendation follows from what it shows — not from what was booked before you arrived.
Step by step
DNA fragmentation testing
We confirm the problem before adding the technique, rather than applying it to everyone.
High-magnification assessment
Sperm are graded on head and vacuole morphology at ultra-high magnification.
Selection
The best-graded or hyaluronan-bound sperm are picked for injection.
Standard ICSI onwards
Injection, culture and transfer proceed exactly as in a normal ICSI cycle.
Your results, in writing
Whatever the outcome of IMSI & PICSI, you leave each stage with the findings written down — what was done, what was found, what it means, and what the options are from here. Reports are issued the same day wherever the laboratory allows it.
What is different about having this done here
Offered only where the indication is documented
DNA fragmentation testing available in-house
Combined with antioxidant therapy and lifestyle correction for the male partner
Costed separately and transparently so you can decline it
Treated by the consultant, not by a rotating team
Dr. Tiwari performs the scans, the procedure and the follow-up herself, and looks after any pregnancy that results. Over a long treatment course that continuity is the difference between being known and being processed.
- MBBS, MS (Obstetrics & Gynaecology), FNB (Reproductive Medicine)
- Over ten years in reproductive medicine and gynaecological surgery
- Previous treatment records from other centres read in full
- Itemised costs given in writing before anything begins
Areas we see patients from
Both clinics are in South Delhi. Patients travelling from further out have appointments grouped to cut down the number of trips.
Questions about IMSI & PICSI
Is IMSI worth the extra cost?
In unselected couples, no. In men with severe morphology defects or high DNA fragmentation, there is reasonable evidence of improved embryo quality. We will tell you which group you are in.
What is a normal DNA fragmentation index?
Below 15% is generally considered normal, 15–30% intermediate and above 30% high. High results usually prompt antioxidant treatment and a repeat test before the cycle.
Talk it through before you commit
Consultations run for a full hour. Bring any previous reports — they are reviewed properly, not repeated.